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Very recently, ToMITA and coworkers' 2) have reported the fermentation, isolation and structure elucidation of gilvocarcins V (1) and M (2). They note that I was previously described under the name of toromycin by HORII et al.3) although the structure of toromycin was not elucidated. Recently we have isolated 1 and 2 and a related compound gilvocarcin E (3) from a culture of Streptomyces anandii subsp. araffinosns strain C-22437 (ATCC-31431).* The producing culture was isolated at BristolLaboratories from a soil collected in Katpadi, Madras, India. We report here the isolation, structure elucidation and biological activities of compounds 1. 3. Isolation of Gilvocarcins V, M and E

Six anthracycline antitumor agents, marcellomycin, musettamycin, rudolphomycin, alcindoromycin, collinemycin, and mimimycin, have now been isolated from bohemic acid complex. This has been achieved by classical column chromatography with Sephadex LH-20 and ammonia-neutralized silica and by analytical and prepatative hplc techniques with normal phase systems containing aqueous ammonia.

While screening cultures of actinomycetes for novel antitumor substances we have isolated an anthracycline mixture, bohemic acid complex, from Actinosporangium sp. strain C36145 (ATCC 31127).1 In addition to the known antibiotics cinerubins A and B2 and pyrromycin,3