This article describes two cases of delayed-onset Cutibacterium acnes ( C acnes ) endophthalmitis 1 month after cataract surgery manifesting with unusual epiretinal deposits. Both patients were referred for persistent inflammation after cataract surgery. After failing to respond to a vitreous tap with injection of antibiotics, the patients underwent pars plana vitrectomy and in one of the cases partial posterior capsulectomy for a posterior capsular plaque. Intraoperatively, both cases were found to have unusual multifocal epiretinal deposits. The clinical presentations described here represent a highly unique manifestation of C acnes endophthalmitis distinct from the classic anterior segment findings. [ Ophthalmic Surg Lasers Imaging Retina . 2022;53:164–167.]

treatment but may not always be necessary. Though P. acnes is the most common cause of delayed-onset postoperative endophthalmitis after cataract surgery, other infectious and noninfectious etiologies must be considered and treated accordingly.