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The outpatient monitoring of the endometrium is mandatory in a defined high-risk population. Countless reports support this thesis. The authors' candidates for screening include initial samples of all patients over 40 years of age, with annual evaluation of a high risk group. This included patients with a family history of endometrial cancer, where the endometrium is subjected to continue estrogen stimulation either exogenous or endogenous, abnormal perimenopausal or postmenopausal bleeding, low fertility, and the medical triad of obesity, diabetes and/or hypertension. The methodology of monitoring is outlined and assessed. The ease of performance, inexpensiveness, and accuracy of 94% had led the authors to support cytology. Combined cytology, histology and hysteroscopy are needed in selected cases.

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