No abstract

The difference is analgesic effect between paracetamol-codeine combinations and paracetamol alone was small but statistically significant. In the multidose studies the proportion of patients reporting a side effect was significantly higher with paracetamol-codeine combinations. For occasional pain relief a paracetamol-codeine combination might be appropriate but repeated use increases the occurrence of side effects.

Values are expressed as mean T SD, t tests, P values (week 24: responders only). Covance laboratory upper limit of normal range for adolescents: males 16.1 Kg/L, females 29.0 Kg/L. LOCF indicates last observations carried forward; NA, not applied.