The use of carbon reinforced polymer (CFRP) to provide lateral confinement for enhanced ductility and strength of reinforced concrete structures has been increasing. The present study, attempts to analytically investigate the effect of the layout of frame columns retrofitted with different layers of CFRP on the seismic performance and damage potential of structures under strong ground motion using realistic and efficient computational models. Based on the shaking table tests of several reinforced concrete (RC) flat slab beamless construction models, the seismic performance of structures strengthened with CFRP composites are investigated. The dynamic response of CFRP retrofitted structures and the components of the model, validation of the model, force-displacement relationship, relative displacement and the time history curves are studied. Then the rational effect of different CFRP layers is found.