Convolutional neural networks (CNNs) are commonly used as artificial intelligence (AI) tools for evaluating radiographs, but published studies testing their performance in veterinary patients are currently lacking. The purpose of this retrospective, secondary analysis, diagnostic accuracy study was to compare the error rates of four CNNs to the error rates of 13 veterinary radiologists for evaluating canine thoracic radiographs using an independent gold standard. Radiographs acquired at a referral institution were used to evaluate the four CNNs sharing a common architecture. Fifty