The coordination chemistry of the two mixed donor macrocyclic ligands R [P 2 N 2 ] (where R [P 2 N 2 ] ) RP(CH 2 SiMe 2 NSiMe 2 CH 2 ) 2 PR, R ) cyclohexyl (Cy) or phenyl (Ph)) with niobium-(III) is presented. The reaction of the dilithio precursors R [P 2 N 2 ]Li 2 (S) (R ) Cy, S ) THF; R ) Ph, S ) 1,4-dioxane) with NbCl 3 (DME) (DME ) 1,2-dimethoxyethane) generates the complexes R [P 2 N 2 ]NbCl (R ) Cy, 1; R ) Ph, 2). For R ) Cy, single-crystal X-ray diffraction studies and variable-temperature magnetic susceptibility measurements indicate that 1 is mononuclear in the solid state; however, analogous variable-temperature magnetic data suggest that 2 is dinuclear in the solid state due to the observation of antiferromagnetic exchange. In solution, 2 is apparently monomeric similar to 1. Adduct formation between these mononuclear complexes is also evident; reaction of 2 with neutral donors and coordinating solvents produces the mononuclear derivatives Ph [P 2 N 2 ]NbCl(L) (L ) py, CO, PMe 3 , THF, MeCN), of which the pyridine adduct, 3e, has been characterized crystallographically. Subsequent replacement of the chlorides can be achieved to generate the paramagnetic alkyl complexes R [P 2 N 2 ]NbR′ (R ) Cy, Ph; R′ ) CH 2 SiMe 3 , CH(SiMe 3 ) 2 ). The representative compounds Cy [P 2 N 2 ]NbCH 2 SiMe 3 (4a) and Ph [P 2 N 2 ]NbCH(SiMe 3 ) 2 (5b) have been characterized by X-ray crystallography.

P Pu ur rp po os se e: : To report a case of desflurane hepatotoxicity.C Cl li in ni ic ca al l f fe ea at tu ur re es s: : An 81-yr-old woman with a remote history of abdominal surgery developed severe acute liver injury after general anesthesia with desflurane for resection of colonic cancer. Serum alanine aminotransferase and aspartate aminotransferase peaked at postoperative day six (2188 and 425 U·L -1 respectively), with the development of coagulopathy with an international normalized ratio of 2.29 on postoperative day eight, progressive jaundice with a peak serum total bilirubin of 214 µmol·L -1 on postoperative day 12 and hepatic encephalopathy on postoperative day ten. Other causes for liver disease were excluded. Treatment with corticosteroids was started. The liver biochemistry normalized completely by postoperative day 30 and the patient was discharged from hospital on postoperative day 21.C Co on nc cl lu us si io on ns s: : To our knowledge, this represents only the third report of desflurane hepatotoxicity and the first with reversible fulminant liver failure. Our experience suggests that all fluorinated anesthetics may cause acute hepatic damage. Objectif : Présenter un cas d'hépatotoxicité au desflurane.