The pattern of hypoperfusion in the placebo state followed by heightened activation with procaine in the cocaine-addicted subjects is similar to the pattern of interictal hypoperfusion and ictal hyperperfusion that has been observed in subjects with epilepsy. The findings for the cocaine-addicted subjects may thus represent evidence of localized (orbitofrontal) sensitization.

No abstract

No abstract

No abstract

Bronchial arteries from sensitized calves contracted on antigenic challenge in the absence and presence of selected anti-allergic drugs and autonomic agents in vitro. Anaphylactic reactivity was inhibited by tripelennamine, isoprenaline and aminophylline, and potentiated by indomethacin and dopamine. Disodium cromoglycate, compound FPL 55712 and ketanserin failed to inhibit anaphylactic contraction.