Necrotizing fasciitis (NF), also known as "flesh-eating disease," is a rapid-acting, potentially deadly infection. This condition is devastating in its ability to spread through the body at an alarming rate. It can be caused by almost any type of injury that introduces microorganisms into the subcutaneous tissues. The initial assessment can be deceptive, so awareness is the key to recognition. This condition often goes unrecognized until it is too late or major disfigurement results. Vital nursing strategies for managing the care of patients with NF include early recognition, accurate assessment, and aggressive treatment.