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Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a multifaceted syndrome, with a vast clinical spectrum. 1 Individuals with 22q11.2DS most commonly experience a range of congenital cardiac defects (CCD), palatal anomalies, dysmorphic facial features, hypocalcaemia, T-cell mediated immunodeficiency, and mild to moderate developmental delays. 1 Nomenclature for 22q11.2DS is diverse, with clinical varied presentations that are essentially different phenotypes of a 1.5 to 3.0 megabase hemizygous deletion of chromosome 22, sometimes in conjunction with other mutations. Consequently, although 'DiGeorge syndrome' and