The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.

Practicing high-risk sports, such as skiing, frequently leads to osteo articular traumatisms requiring complex surgery. The postoperative period is often painful, even when major analgesic medications are used. We report 2 cases of ski accidents: one involving a knee twist, the other a complex dislocation of the shoulder. Both resulting in a very painful postoperative recovery time. In one case, exposure of the wrist to low level electromagnetic wave in the millimetric frequency (MMW, 60GHz, continuous wave) by means of a device designed for wellness or to improve or initiate sleep, resulted in almost complete pain relief and the removal of analgesics, allowing active rehabilitation. While the results in the other case seemed less spectacular, the use of the device provided physiological support to the mechanism of the MMW's analgesic properties.

Glioblastoma are malignant tumors of the central nervous system with generally a lethal issue within 15 months whatever the classical therapeutics. Several studies showed promising results using alternative electric or magnetic fields, or nanoparticles (mainly iron) combined with an alternative magnetic field. Besides, Carbon Nanotubes (CNTs) have very special physicochemical properties potentially synergistic with non-ionizing radiation (EMF, including ultrasound from a piezo component) exposure. The aim of this first note was to the effects of a co-exposition from carbon nanotubes and electromagnetic field on an in vitro C6 glioma model growth and viability, using model probe associating EMF (100KHz, square signal, 10Vpp) and piezo emission with a local CNTs deposit. A strong synergic effect between EMF and CNTs as the C6 cell population decrease with these two factors. Respectively, 10%, 25% and 51% population decrease for the Sham / Field, Sham / Nano and double exposed group compared to the control group. However, the survival rate of the cells is poorly affected after 72h exposure time (more than 90% survival rate). These promising results should be used to a miniaturized implantable probe center in order to propose a new therapeutic approach using an intra tumoral catheter (including an EMF emitter), allowing the distribution of CNTs (or chemotherapy) using the convective infusion technique.