Graphene nanoribbons on highly porous 3D graphene foam as the binder-free cathode for flexible Al-ion batteries exhibit low charge voltage, high capacity, excellent cycling ability (even after 10 000 cycles there is no capacity decay), and fast charging and slow discharging performance (the battery can be fully charged in 80 s and discharged in more than 3100 s).
Caspase-11 is a key regulator of proinflammatory cytokine IL1b maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological stimulation such as in the presence of lipopolysaccharide (LPS). Here, we describe the identification and characterization of wedelolactone, a natural compound that inhibits LPS-induced caspase-11 expression in cultured cells by inhibiting NF-jB-mediated transcription. We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critical for activation of NF-jB by mediating phosphorylation and degradation of IjBa.
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