To study the Effect of Physiotherapy on Fatigue Psychological Stress in Cancer Patients during the Course of Chemotherapy. Subjects fulfilling the inclusion and exclusion criteria were included. Prior consent was taken and assessment of their fatigue, stress level and pain was done using the brief fatigue inventory, Cohen perceived stress scale and brief pain inventory. Based upon the findings, a tailor made protocol was given to the patients, wherein 3 sets of each exercises 5times a week for a month’s duration had to be followed. The exercises were altered as per the patients’ requirements and capability. Each session conducted was of 35-45min duration which began with Warm-up Exercises including Stretching for 10min, followed by 6 Minute Walk for 6minutes, Harvard Step for 3 minutes and the session was concluded with a Relaxation period of 20minutes. For relief of pain, TENS was given during the Relaxation period. After the 6minute walk, patient’s exertion was checked by the Borg Scale. The exercises were prescribed according to FITTs principle. Statistical analysis was done using unpaired t test. In this study, pre-intervention Brief Pain Inventory was 71.90±12.33 and post-intervention was 61.03±11.47. In Brief Pain Inventory statistically extremely significant difference and decrease in pain post intervention with (p< 0.0001) with t= 7.028. Pre-intervention Brief Fatigue Inventory was 53.83±11.03 and post-intervention was 41.78±13. In Brief Fatigue Inventory statistically extremely significant difference and decrease in fatigue post intervention with (p=<0.0001) with t=9.57. Stress assessment by Cohen Perceived Stress Scale was 21.71±2.27pre treatment and 19.86±2.23 post treatment. In Cohen Perceived Stress Scale, statistically extremely significant difference and decrease in stress level after treatment with (p=<0.0007) with t=4.998. Pre-treatment Rate of perceived exertion was 12.49±3.23 and post treatment was 10.34±2.94.In Rate of Perceived Exertion statistically significant difference and decrease in exertion level post treatment with (p=<0.0007) with t=8.945. Thus the above concludes that physiotherapy had significant improvement clinically and statistically on fatigue and stress in cancer patients undergoing chemotherapy. So this study accepts the alternate hypothesis.

Background: Combination vaccines have many benefits but sometimes may result in unexpected side effects which may make the vaccine unfit for administration particularly with multidose vials.Methods: Healthy infants aged 6-8 weeks who came for routine immunization of liquid pentavalent vaccine were included in the study. All infants were observed for 30 minutes, post vaccination. Telephonic interview was conducted to detect AEFIs at 1 week and 1 month post vaccination.Results: The common AEFIs were found to be fever and pain at injection site. A comparison of the incidence (per 100 doses) of AEFIs after 1st, 2nd and 3rd dose of pentavalent vaccine showed that AEFIs goes on reducing with dose. Incidence (per 100 doses) of fever and local AEFIs was more (statistically significant) with multi-dose vial pentavalent vaccine.Conclusions: The multi-dose vial liquid pentavalent vaccine was found to be equally tolerable compared to single-dose vial liquid pentavalent vaccine.

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