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Introduction: The aim of the study was to observe haemodynamic changes during induction of patients undergoing CABG with Propofol and Pentothal. It was also intended to see if fixed dose combination of premedication with midazolam and fentanyl helps to reduce dose requirement of induction agents. Material Methods: 60 ASA grade II patients posted for elective Coronary Artery Bypass Surgery (CABG) were divided into two groups. Group I (propofol group) and group II (pentothal Group). All patients received premedication as Inj.Midazolam 0.03 mg/kg and Inj.Fentanyl 4 µg/kg. With computer generated randomization patient was allotted to either propofol or Pentothal group. End point of induction taken as loss of eyelash reflex or apnoea whichever appears first. Hemodynamic parameters were recorded from baseline till 7 minutes post intubation. Results: In both the groups SBP, DPB, MAP, HR and RPP were found to be comparable. Both the drugs showed stable hemodynamic at various levels of observations. The mean dose required for induction was found to be 1.7 mg/kg with propofol and 1.07 mg/kg with Pentothal. Conclusion: Both propofol and Pentothal are equally able to provide required stability even when standard doses of benzodiazepines and opioids are used in much lower doses than mentioned in literature.

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