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The nasolabial flap is a well-known flap for the reconstruction of nasal, labial, and intraoral defects. Successful use of inferiorly based nasolabial flaps in the management of oral submucous fibrosis (OSMF) is projected in this article. We evaluated the use of nasolabial flap in the management of five patients with histologically confirmed OSMF. They all had interincisal opening of less than 20 mm and were treated by bilateral release of fibrous bands, measurement of intraoperative interincisal distance (greater than 35 mm achieved in all patients after release of bands), covering the defects with inferiorly based nasolabial flap. All patients had postoperative physiotherapy and were followed up regularly for 1 year. All flaps healed without evidence of infection, dehiscence, or necrosis.