Introduction: Hypertension has been known to be a decisive factor for stroke in the elderly; however, limited studies reported stroke risk factors in subjects with isolated systolic hypertension (ISH). Methods: This cross-sectional survey was conducted using Riskesdas 2018 secondary data. Subjects aged 55 years who had a systolic blood pressure ≥140 mmHg and diastolic < 90 mmHg were included as the study sample. According to the National Institute of Health Research and Development, the Ministry of Health, Republic of Indonesia, all study variables were measured using household and individual questionnaires. The data were analyzed using the chi-square test and Fisher's test. Results: Of 3159 subjects with ISH 8.3% had a stroke, the risk factors that had a significant relationship with the prevalence of stroke (p<0.005) were gender (1,790; 1,420-2,256), smoking habits (1,645; 1,291-2,096), physical and mental stress (2,080; 1,618-2,673), area of residence (1,720; 1,331-2222), and education level (0.656; 0.515-0.835). Conclusion: Prevalence of stroke among ISH in Indonesia was 8.3%. Female with smoking habits, had mental and physical stress, liviing in urban area, and had low level eduatcion were associated with the status of stroke in ISH subjects in Indonesia.