Samdrup Jongkhar district has reported an increasing trend in infant mortality rates over the recent years. This study aimed to identify its determinants. A population based case-control study was conducted in May 2018. Case group comprised of 79 infants who died between 1st January 2015-30th April 2018 while 158 living children born during the same period and residing closest to the home where infant mortality occurred were recruited as controls. Premature new-borns and those with low birth weight were 5.9 times and 4.1 times more likely to die respectively. New-borns whose mother received better ante-natal and post-natal care were more likely to survive. Over 50% of the deaths occurred at home and around two-thirds of deaths occurred during the post-natal period. Implementing a multi-stakeholder collaborative approach including local leaders, village health workers and religious leaders would be useful in reassuring parents to seek early medical care during childhood illness.
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