Changes in the body in the presence of a chronic inflammatory process, even of a low intensity, lead to the change in the body’s reactivity, having a negative impact on the development, course and clinical prognosis of newly emerging inflammatory processes. Structural changes in the vascular network in the focus of chronic inflammation and following cellular reactions that occur under the action of chemokines and cytokines are the basis for the maintenance and development of the phlogogenic process, including subsequent structural changes in tissues. The failure to resolve the inflammation leads not only to the persistence of the process in the primary focus, but also to the formation of a multitude of the so-calledpathological circles, included at the system level, causing the imbalance among proinflammatory, anti-inflammatory and pro-resolving factors. As a result, conditions are formed for the emergence of new foci of the inflammation in other organs and tissues and in the case of their realization, new vicious circles are formed that contribute to the maintenance and progression of the inflammation. The complex application of etio-tropic, pathogenetic and sanogenetic principles of the treatment allows intensifying of the formation of specialized pro-resolving factors with the elimination of their relative insufficiency, contributing to the reduction of newly formed vessels and to the restoration of the normal cellular composition of the tissue as well as to the resolution of inflammation.

The authors demonstrate the importance of individual criteria for the choice of dosed physical load for the patients with cardiological problems during hospitalization. The analysis of the functional state and hemodynamic parameters included 68 patients with various cardiovascular diseases before and after performance of the special program ofphysical rehabilitation. The results suggest high efficiency of the proposed treatment and good prospects for further studies in this field.

The basis of coronavirus disease is an infectious process, accompanied by a varying degree of activity of pathological processes. Based on the study of the pathological course of infection, modern approaches to the treatment and prevention of complications of coronavirus infection are presented. The main strategic pathogenetic direction in the creation of effective programs for the treatment of COVID-19, as well as the prevention of fatal complications, should be a set of measures enhancing permissive regulatory influences and events. Endothelium, being a source of inflammatory mediators and a transducer of their regulatory effects on the vascular tone, is involved in the development and alternation of vascular reactions, changing the volume of perfusion. The main mechanism for the development of endothelial dysfunction and damage is associated with an imbalance between the generation of reactive oxygen species and the power of the antioxidant defense system. Any measures to protect the endothelium, reducing the severity of microcirculatory disorders and hypoxia, will have a therapeutic and preventive effect on fatal complications. In this regard, in the treatment of COVID-19, the use of synthetic gas transport preparations based on perfluorocarbon nanodispersed emulsions with a clinical effect directed at once to several patho-genetic links underlying the progression of COVID-19 disease can be quite effective. The necessity of a comprehensive effect on pathogenesis using sanogenetic principles of treatment, allowing influencing the speed and time of onset of resolution of inflammation, which can reduce the number of complications and deaths of the disease, is substantiated.

In some cases, the parameters of the stump may undergo changes while walking on the prosthesis of the thigh or lower leg. The volume of the stump can change rapidly with certain pathologies (vascular diseases, multiple cicatricial changes), while a temporary increase in volume can occur in case of, for example, overload. In other cases, the parameters change gradually and, as a rule, downward. The result of a change in their volume is a change in the distance of the greater trochanterfloor, which leads to temporary or permanent overload of individual muscle groups when walking, a change in gait, and the formation of secondary changes from the various structures of the musculoskeletal system. The use of an insert in the carrier module in the form of a prosthesis length corrector allows to improve the quality of the rehabilitation and life of the disabled person and also avoids a significant number of secondary complications.

In the mid-end of the last century, unification was carried out to select the level of limb trimming, based on the principle of achieving the maximum possible functionality in the stump-prosthesis system. Over time, due to the development of surgical techniques and the level of prosthetic and orthopedic products, previously developed schemes for choosing the level of amputation have lost their relevance. However, the most typical complications and the associated decrease in prosthetics functionality continue to occur in the current time period. The article provides an analysis of the possible variants of complications in relation to the level of limb truncation, options for their prevention and elimination, and how the general assessment of the effect on the stat-dynamic function of the stump length at various levels is presented.