Breast cancer cT1-4N0M0 patients usually require a sentinel lymph node biopsy. Sentinel lymph node biopsy with indocyanine green fluorescence detection is a modern technique with a high lymph node detection rate. However, the false-negative rate was not evaluated adequately. Our objective was to determine node detection rate and the false-negative rate. 99 patients with 100 cases of breast cancer cT1-4N0M0 were operated on. The axillary part of an operation consisted of indocyanine green fluorescence-guided SLN biopsy and an axillary lymphadenectomy of levels I-II or I-П-Ш. A signal lymph node was detected in 98 cases (98 %). In 28 (28.6%) cases out of 98, metastases in signal lymph nodes were found. Other than sentinel lymph node had metastatic lesion only in 35.7% in SLN N+ cases. False negative result occurred in 1 case of 28 (3.6%). The application of indocyanine green fluorescence-guided sentinel lymph node biopsy in cN0 breast cancer patients allows for a high signal lymph node detection rate and a low false negative rate.

In this study there was evaluated the possibility to perform one-stage reconstructive and plastic operations (RPO) in III stage breast cancer (BC) cases. There were analyzed two similar groups of patients, depending on the volume of the operations: in the 1st (main) group there were carried out RPO of different kinds of simultaneously with radical mastectomies (RME), in the 2nd (control) RMEs with preservation of pectoral muscles. There were analyzed overall survival (OS), disease-free survival (DFS); the frequency ofpostoperative complications and aesthetic results of the treatment. 3-, 5- and 10-year OS and DFS in group statistically did not differed significantly (p > 0.05). The rate of postoperative complications was in the group of patients who undergone RPO by TRAM-flap accounted of 8.3%, in the RME group - 6.9% (p> 0.05). The aesthetic results of the treatment: satisfactory in RPO, unsatisfactory - in RME.