HBoV is circulating in the United States and is associated with both upper and lower respiratory tract disease in infants and young children.

HBoV infection is common during childhood, but a minority of children and young adults screened have evidence of B19 infection.

We report a 19-year-old man with pulmonary squamous cell carcinoma (SCC) who had a history of vertebral, anal, cardiac, tracheal, esophageal, renal, and radial limb defects (VACTERL) association and tracheoesophageal fistula (TEF) + esophageal atresia (EA) repair as an infant. Children that undergo TEF + EA repair may have an increased risk for developing cancer as they reach adulthood.

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