Aim: The aim of the study is to determine the relationship of some trace elements and heavy metals with lip and oral cavity cancer. Materials And Methods: Blood counts of 21 individuals with lip and oral cavity cancer were compared with those in the control group consisting of 30 volunteer and healthy subjects. Levels of trace elements and heavy metals in the serum (Zn, Cu, Mg, Pb, Mn, Cd, Co and Fe) were determined using Atomic Absorption Spectrophotometer method at YUU Central Research Laboratory (Spectrometer: Thermo Scientific C103500100, China). Findings: In this study, the descriptive statistics and comparison results for Cu, Mn, Mg, Fe, Zn, Co, Pb, Cd were found to be statistically significant (p <0.05). According to these results, Zn, Fe, Mn, Mg and Cu levels which are necessary trace elements for human body were found to be significantly lower in patients than healthy control groups. Cd, Co and Pb levels which are harmful and toxic to human body were found to be significantly higher in patients than healthy control groups (p <0.05). Results: Based on these findings of this first and new study in the literature, it was concluded that, trace elements and heavy metals (Cu, Mn, Mg, Fe, Zn, Co, Pb and Cd) in the lip and oral cavity may affect the etiopathogenesis of the disease.
