Highlights d AstA/AstAR1 signaling times the onset of maturation by promoting PTTH secretion d AstA/AstAR1 promotes juvenile growth by controlling Dilps secretion in the IPCs d AstA N1 neurons coordinate growth and maturation during larval development d AstA/AstAR1 achieves maximal activity in PTTH neurons at maturation onset
Increased IFN-gamma/TGF-beta production and reduced IL-35/IL-17/SOCS3 production in preeclamptic women may lead to less cytokine inhibitory activity in PE, which may account for the increased proteinuria and blood pressure in PE.
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