Bladder cancer is a malignant tumor that occurs on the mucous membrane of the bladder. It is the most common malignant tumor of the urinary system and one of the top ten common tumors in the whole body. This bibliometric analysis was applied to identify the characteristics of global scientific output, the hotspots, and frontiers about treatment on bladder cancer with Chinese medicine monomer over the past 22 years. We retrieved publications published from 2000 to 2021 and their recorded information from Web of Science Core Collection (WoSCC). VOSviewer and CiteSpace were used to analyze bibliometric indicators and visualize the trend and hotspots of researches on bladder cancer with Chinese medicine monomer. Altogether, 658 original articles were reviewed, and the results showed that the annual number of publications (Np) shows an upward trend over the past 22 years as a whole. The US produced the most papers, and the number of citations (Nc) and H -index of the US ranked first. Johns Hopkins University and BJU International were the most prolific affiliation and journal, respectively. Recently, the keywords “NF-kappa B” appeared frequently. Besides, quercetin is the most thorough research in the treatment of bladder cancer with Chinese herbal compound, but whether quercetin is the most potent compound needs further study.