The importance of respiration rates and oxygen saturation (SpO2) monitoring and the high need for oxygen therapy opens the opportunity for the development of non-invasive respiration rate and oxygen saturation monitoring and controlling system. There are two modes of controlling in this system, automatic and manual mode. In automatic mode, the oxygen flow rate is based on the measurement of the respiration rate using the MLX90614 temperature sensor and tidal volume determination based on the patient’s body weight. Oxygen flow control uses a DC motor to open and close the oxygen regulator valve. Oxygen flow will stop when the respiration rate and oxygen saturation level are normal. Oxygen saturation is measured using the MAX30100 sensor. The fabricated regulator control system is capable of flowing oxygen by 5-8 liters per minute using an oxygen mask. The respiration rate measurement was compared with the palpation test, and the deviation was 0.99%. Oxygen saturation reading that used MAX30100 as an oximeter sensor was compared with pulse oximeter fingertip reading, and the deviation was 1.62%. The average flow deviation between the fabricated regulator control system and the calibrated regulator is 2.93%. The result of measuring the response time of the motor for an increase of one liter per minute (LPM) is 1.54 seconds.