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An endophyte fungus, Clonostachys rosea, which was isolated from mangrove plants, was subjected to a one-strain-many compounds (OSMAC) strategy. We have shown that modification of culture media enhanced the productions of secondary metabolites by C. rosea. It was found to produce four new compounds and one known compound, (-)-vertinolide (1), in a medium of rice with commercially apple juice.Furthermore, (-)-dihydrovertinolide (2) was phytotoxic action in lettuce seeding at a concentration of 50 mg L -1 .

A new limonoid, pentandricine (1), along with three known limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3), 6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been isolated from the stembark of Chisocheton pentandrus. The chemical structures of the new compound were elucidated on the basis of spectroscopic evidence. All of the compounds were tested for their cytotoxic effects against MCF-7 breast cancer cells. Compounds 1-4 showed weak and no cytotoxicity against MCF-7 breast cancer cells with IC values of 369.84, 150.86, 208.93 and 120.09 μM, respectively.