Telah dilakukan penelitian tetang Formulasi Sediaan Gel Ekstrak Etanol Daun Senduduk (Melastoma malabathricum L.) Terhadap Uji Kestabilan Fisik dan Uji Aktivitas Antibakteri  Pada  Staphylococcus Aureus. Penelitian ini bersifat eksperimental dengan membuat 3 jenis formula gel yang mengandung ekstrak etanol daun senduduk (Melastoma malabathricum L.) 4% dengan memvariasikan HPMC sebagai gelling agent pada konsentrasi 3%, 3,5% dan 4%. Uji aktivitas antibakteri dilakukan dengan metode difusi agar terhadap bakteri Staphylococcus aureus. Sediaan disimpan selama 28 hari dan dievaluasi pH, viskositas, homogenitas, intensitas warna dan bau serta iritasi kulit  pada hari ke-0, ke-7, ke-14, ke-21 dan ke-28. Metode: Data uji kestabilan fisik yang diperoleh disajikan dalam bentuk tabel dan grafik lalu diinterprestasikan. Sedangkan untuk uji aktivitas antibakteri cara pengolahan dan analisis datanya yaitu menggunakan analisa statistika  One Way ANOVA yang dilakukan dengan cara mengukur diameter zona hambat. Hasil:  menunjukan bahwa semakin tinggi konsentrasi HPMC (gelling agent) maka semakin tinggi viskositas dan semakin rendah daya sebar dan pH, namun tidak berpengaruh terhadap homogenitas, warna, bau dan iritasi kulit. Hasil uji antibakteri menunjukkan bahwa pada formula ekstrak I zona hambat berkisar 11 – 16,5 mm, formula II zona hambat berkisar  10 – 16 mm dan pada formula III   zona hambat berkisar 10 – 14,5 mm.   Uji statistik oneway anova (p<0,05) untuk membandingkan zona hambatan pada sediaan pada hari ke-0, ke-7, ke-14, ke-21 dan ke-28, didapatkan signifikasi 0,412 (p>0.05). Kesimpulan:  Sediaan gel yang mengandung Ekstrak etanol daun senduduk pada Formula I mempunyai kestabilan fisik yang memenuhi persyaratan untuk dibuat sediaan gel.

Foot heel is very susceptible to Xerosis due to lack of moisture due to loss of lipids and natural moisturizing factors in the Stratum Corneum. According to research, Papaya Leaves (Carica papaya L) contain phenol compounds which are secondary metabolites which play an active role as antioxidants and antimicrobials. This study aims to examine whether papaya leaf extract (Carica papaya L) can be formulated as a Foot Lotion by varying the concentration of Triethanolamine as an emulgator and performing a physical stability test. This study uses an experimental method. Papaya leaf extract (Carica papaya L) as much as 10% as the active ingredient and vary Triethanolamine as an emulgator with a concentration of 3% in formula I; 3.5% in formula II; and 4% in formula III. Then a 28-day preparatory evaluation was made that the pH results of foot lotion preparations with formula III were more stable than formulas I and II while the results of the viscosity of all formulas were required. All formulas increase and decrease in the spread diameter in each week but remain in the range of 5-7 cm and do not change color, smell and do not irritate the skin. Judging from the spread, homogeneity, color, odor and skin irritation, the three formulas met the requirements for 28 days of storage. Papaya leaf extract (Carica papaya L) can be formulated into a stock of lotion that is stable and meets the requirements. The most stable footlotion formula is formula II with a variation of 3.5% Trietanolamine concentration.

Background: The form of soap that has not been widely circulated in the market is soap in sheet form or in paper form. The sheet form will provide an advantage, which is easy to store and can be carried anywhere, and the use of one sheet at a time can maintain the quality of the soap. One of the natural active ingredients that have an antibacterial effect are the leaves of the mother-in-law's tongue leaf plant (Sansevieria trifasciata Prain) and the aloe vera (Aloe vera L.) leaf extract. This study aims to formulate the Ethanol Extract of Aloe Vera Leaf (Sansevieria trifasciata Prain) and Aloe Vera Leaf Ethanol Extract (Aloe vera L.) into paper soap preparations that meet the requirements.   Methods: The method used is experimental by making paper soap from mother-in-law's aloe leaf extract and aloe vera extract by making formulas I, II, III with 10%, 15% and 20% percentages of aloe vera extract, while the percentage of aloe vera extract is 3%, 6 % and 9%. And evaluation of the preparation was carried out for 28 days, and Test the effectiveness of Gram positive bacteria (Staphylococcus aureus) and Gram negative bacteria (Escherichia coli). Results: During 28 days of storage, the preparation of soap made from pH-stable paper tends to decrease as well as foam stability and free fatty acid content, but it still meets the requirements of SNI. The results of the organoleptic test of methamphetamine preparations made from paper did not change the smell and color, and did not irritate the skin, And has an inhibitory effect on the growth of Staphylococcus aureus bacteria. Conclusion: Paper soap with ethanol extract of mother-in-law's tongue (Sansevieria trifasciata p.) and ethanolic extract of aloe vera leaf (aloe vera L.) can be formulated into paper-based soap preparations that are stable and meet the specifications required by the Indonesian National Standard (SNI) and are able to inhibit growth. Staphylococcus aureus and Escherichia coli. The most optimal formula in Formula II with varying concentrations of a mixture of 15% aloe vera leaf ethanol extract and 6% aloe vera leaf ethanol extract .

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ABSTRACT Background: As a producing country and at the same time the largest consumer of tempeh in the world, Indonesia has become the largest soybean market in Asia. As much as 50% of soybean consumption in Indonesia is done in the form of tempeh. Tempe is a potential food ingredient as a hepatoprotector. The content of isoflavones in tempeh has been shown to protect rat liver function under stress conditions. Isoflavones contained in tempeh have activity as antioxidants, which can prevent oxidation reactions from occurring by working as reducing agents and protecting cell membranes from oxidation, as well as counteracting free radicals by stopping chain reactions and protecting cells from DNA activation so as to reduce cell damage. This situation has prompted the authors to investigate the effect of the isoflavone extract of tempeh on the histochemistry and histopathology of the livers of male white Wistar rats (Rattus novergicus) after being induced by toxic doses of Paracetamol. Methods: This study was an experimental study using the Randomized Posttest Only Control Group Design to determine the level of oxidative stress after administration of tempeh isoflavone extract to male white rats (Rattus novergicus) induced with a toxic dose of paracetamol. 5 groups, namely group 1 was given tempe extract 160 mg/kgBB, group 2 was given tempe extract 320 mg/kgBB, group 3 was given tempe extract 640 mg/kgBB, group 5 was given distilled water and group 6 was given 1% NaCMC solution. Each rat was treated for 14 days. On day 12, 13 and 14 rats were given paracetamol at a dose of 900 mg/kg BW in 1% NaCMC. And on the 15th day, rat blood serum was examined for levels of SGOT, SGPT and MDA. Results: It was found that tempeh at a dose of 640 mg/kgBW could significantly reduce SGOT, SGPT and MDA levels (p<0.05) compared to other doses as well as distilled water and 1% NaCMC. Conclusion: So it can be concluded that tempeh can be an alternative source of antioxidants that can protect liver cells from the effects of substances that can damage the liver. Keywords: Tempe, SGOT, SGPT, MDA