Noroviruses (NVs) are the most frequent cause of outbreaks of gastroenteritis in common settings, with surface-mediated transfer via contact with fecally contaminated surfaces implicated in exposure. NVs are environmentally stable and persistent and have a low infectious dose. Several disinfectants have been evaluated for efficacy to control viruses on surfaces, but the toxicity and potential damage to treated materials limits their applicability. Sterilox hypochlorous acid (HOCl) solution (HAS) has shown broad-spectrum antimicrobial activity while being suitable for general use. The objectives of this study were to evaluate the efficacy of HAS to reduce NV both in aqueous suspensions and on inanimate carriers. HOCl was further tested as a fog to decontaminate large spaces. HOCl effectiveness was evaluated using nonculturable human NV measured by reverse transcriptase PCR (RT-PCR) and two surrogate viruses, coliphage MS2 and murine NV, that were detected by both infectivity and RT-PCR. Exposing virus-contaminated carriers of ceramic tile (porous) and stainless steel (nonporous) to 20 to 200 ppm of HOCl solution resulted in >99.9% (>3 log 10 ) reductions of both infectivity and RNA titers of tested viruses within 10 min of exposure time. HOCl fogged in a confined space reduced the infectivity and RNA titers of NV, murine NV, and MS2 on these carriers by at least 99.9% (3 log 10 ) , regardless of carrier location and orientation. We conclude that HOCl solution as a liquid or fog is likely to be effective in disinfecting common settings to reduce NV exposures and thereby control virus spread via fomites.Noroviruses (NVs) are the leading cause of nonbacterial gastroenteritis worldwide and are estimated to be responsible for 80 to 90% of reported outbreaks, particularly in public settings such as cruise ships, hotels, and health care facilities (19,25). NV outbreaks in these common settings have economic impacts resulting from the costs to disinfect affected areas to prevent the spread and recurrence of NV infection, the likely shutdown of workplaces, and the hospitalizations of affected persons. The main modes of transmission are via the fecal-oral route by consumption of contaminated foods or water (4,5,26,27), by direct or indirect person-to-person transmission via hands or fomite transfer (11,12,14,17,23,35), or by airborne contamination. NV outbreaks are difficult to control due to the viruses' having high attack rates, environmental stability, and a low human infectious dose estimated to be between 10 and 100 virions per 50% human infectious dose (10).Chemical disinfection is an effective measure to interrupt the environmental spread of infectious viruses. However, the effectiveness of antimicrobial agents is highly influenced by the type of virus, by exposure conditions such as organic loading and contact time, and by biocidal activity and concentration. Generally, glutaraldehyde and sodium hypochlorite are known to be effective against nonenveloped RNA viruses, such as NVs, whereas detergents and most lipophi...