Graphical abstract

BackgroundPreparation of some novel heterocyclic compounds with long alkyl and alkenyl chain of cytotoxic activity.MethodsGamma linolenic acid, a poly unsaturated fatty acid and stearic acid, a saturated fatty acid were isolated from the microalga Spirulina platensis. Some novel gamma linolenic acid and stearic acid analogues having 1,3,4-oxadiazole and 1,2,4-triazole were synthesized and characterized by IR, 1H NMR, 13C NMR and mass spectral analysis. Cytotoxicity of these compounds was evaluated by the growth inhibition of A-549 cells in-vitro.ResultsCompound 1 and 3 showed comparable cytotoxicity against the human lung carcinoma A-549 cell lines.

Structure-based insilico-guided screening of potential polytargeting anti-COVID phytochemical: gallocatechin gallate analogue.

: The fabaceae are rooted in rosaceae pods known as "vegetables" by the early botanists. They are the third family of angiosperms which includes 642 genus divided into about 18,000 species. The fabaceae family is known as the most important family of the ecosystem as it is indispensable in medicine, agriculture, industry and livestock. The Adenocarpus genus has about 50 species that are frequently found in tropical regions of Northern Africa, the southern part of West Europe and in the central and southern Italy. They are used in traditional medicine for the treatment of several diseases: such as microbial infections, leprosy, scabies, acne, malaria and other plants species are used in agriculture as insecticidal properties. Mainly Adenocarpus mannii species is well represented in the tropical regions of North Africa. It occurs in Angola, Mozambique, Malawi, Guinea, South Africa, Tanzania, and Burundi. In Cameroon, it is encountered in South West Region and West Region. Previous phytochemical studies led to the isolation of several classes of compounds such as flavonoids, alkaloids and triterpenes. Several studies report the phytochemical studies on genus Adenocarpus and chemotaxonomic markers of species of this genus. Herein, we outline all the botanical, pharmacological and phytochemical aspects of Adenocarpus mannii. A brief introduction about fabaceae and the genus Adenocarpus has also been included.