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A series of new sulfonamides have been synthesized from Ampyrone with different benzene sulfonyl chlorides to yield the -1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1-pyrazol-4-yl) benzenesulfonamides (-). All synthesized compounds were characterized on the basis of FTIR, H NMR, andC NMR, and also by the aid of mass spectral data. Further, all synthesized compounds have studied for their in vitro antimicrobial activities against selected bacterial as well as fungal strains by the agar well diffusion method. Free radical scavenging activity has been investigated by using DPPH method. Among all the synthesized compounds, ,, and exhibited significant antimicrobial and antioxidant activities.

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Various derivatives of 1,2-dihydro-6-(4-hydroxy-5-isopropyl-2-methylphenyl)-2-oxo-4-arylpyridine-3-carbonitrile (IVa-m) were synthesized and characterized. Their antioxidant and antimicrobial properties were evaluated by measuring their activity in vitro. Among the newly synthesized derivatives IVg, IVh, IVi, IVj, IVk, IVl, and IVm showed good antioxidant activity. However, all derivatives show better antibacterial and antifungal properties than that of parent thymol. The probable mechanism, particularly for antioxidant properties of these compounds is proposed.

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