Objective:The main objective is to investigate the antidiabetic, antihyperlipidemic and antioxidant activity of methanolic extract of Cordia obliqua (MECO) in streptozotocin-induced diabetic rats. Methods: Acute toxicity study of MECO was carried out in rat to determine its dose for further study. Oral glucose tolerance test was performed to evaluate MECO on elevated blood glucose levels. Diabetes was induced in rats by administration of streptozotocin (STZ) (45 mg/kg) and it was confirmed 3 days after induction. The methanolic extract of Cordia obliqua (MECO) was orally given to the diabetic rats up to 21 days and the blood glucose levels were estimated at the end of each week. On 21st day of the experiment, rats were sacrificed after the blood collection for the biochemical, antioxidants in kidney and pancreas was isolated for histopathological observation. Results: Acute toxicity MECO did not show toxicity and death up to a dose of 2000mg/kg in rats. MECO 200mg/kg and 400 mg/kg doses significantly (P<0.005) reduced blood glucose levels in OGTT. Both the doses MECO treatment significantly (P<0.005) increased the body weight, HDL by dose dependently when compared with STZ treated rats. Also, MECO treated rats significantly (P<0.005) decreased the blood glucose, SGOT, SGPT and ALP when compared with STZ treated rats. Normalized the lipid, antioxidant levels were reversed to near normal in diabetic rats treated with MECO. Conclusion: From the above results it was concluded that the plant extract having the ability of managing hyperglycemic and complication of diabetes in STZ induced diabetic rats. Hence this plant may be considered as one of the source for the isolation of new oral anti hypoglycemic agent. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Aim: To evaluate the anti-amnesia effect of Bauhinia purpurea in Scopolamine induced amnesia in rats. Materials and Methods: A total of 30 rats were divided into 5 groups 6 rats in each. Group I considered as normal control. Group II served as negative control. Group III, IV and V were treated with Donepezil (3 mg/kg), ethanolic extract of Bauhinia purpurea 200mg/kg and 400 mg/kg respectively for 14 consecutive days followed by single administration of Scopolamine (3 mg/kg) to all the groups except group I. Cognitive performance was assessed by the Morris water maze, elevated plus maze and passive avoidance paradigm. Acetyl cholinesterase enzyme level, biochemical markers such as lipid peroxidation, reduced glutathione and β amyloid 1 42 level, Neurotransmitters including dopamine and serotonin and histopathological study of rat brain were estimated. Results: Bauhinia purpurea and Donepezil rats showed significant increase in escape latency, step-through latency and decreased transfer latency in respective cognitive models of the Morris water maze, passive avoidance test and elevated plus maze. Additionally, Bauhinia purpurea extract remarkably promoted the cholinergic neurotransmission, decreasing β amyloid protein and protected against the oxidative stress damage as indicated by, increasing reduced glutathione level, lowering the level of lipid peroxidation, restored dopamine and serotonin level in the brain. Furthermore, histopathological studies revealed the reversal of neuronal damage in the treatment group compared to Scopolamine treated rats. Conclusion: Bauhinia purpurea extract showed promising antiamnesia activity against scopolamine induced amnesia in rats. This could be attributed to its brain acetyl cholinesterase level, β amyloid level inhibition, antioxidant activity and alteration in neurotransmitters level.