Due to the presence of starting pressure of low permeability reservoir, so researching on starting pressure gradient of low permeability reservoir is necessary. while starting pressure gradient is relevant to permeability and porosity, it can be obtained through laboratory experiments¡¢well testing interpretation method¡¢theory derivation combined with practical application method . The result of a large number of laboratory experiments shows: starting pressure is related to permeability .The greater the permeability is, the smaller the starting pressure is. They both present the similar hyperbolic relationship; the greater the viscosity of the oil is, the greater the starting pressure is. In this paper, we get the starting pressure gradient formula through the method of theory derivation combined with practical application, meanwhile we put forward the relationship between starting pressure gradient and permeability, porosity¡¢viscosity .