Background: The Regulatory-Sensory Processing Disorder (RSPD), defined on the diagnostic manual DC: 0-3 R as "the child's difficulties to regulate his own behaviour, his physiological, sensory, attention, motor or affective processes and difficulties in organizing a state of calm, of alert or a positive affective state", is a neurodevelopmental disorder of the early infancy for which it has not yet been determined a clear etiopathology. Clinical practice has led us to hypothesize an association between "minor" injuries of the white matter, in particular periventricular hyperyntensities (PVHs) and RSPD.