Background: Meningiomas are common central nervous system neoplasms, accounts for 30% of all primary intracranial neoplasms; the occurrence of meningiomas with cystic lesions is an exceptionally rare. Lymphoplasmacyte-rich meningioma (LPRM) is a rare pathological entity belong to the World Health Organization Grade I meningiomas. LPRM is characterized by abundant lymphoplasmacytic infiltrates which over-shadow the underlying meningothelial component. Case Description: A 42-year-old male was admitted to our hospital with a chronic headache for about 3 weeks prior to admission. His symptoms worsen, and subsequently, he experienced left extremities weakness about 1 week before admission. His brain magnetic resonance imaging revealed an irregular and heterogeneously enhancing solid lesion with intratumoral cystic changes at the temporal lobe. A gross total resection was performed; pathological examination revealed a cystic LPRM. Conclusion: This rare variant of meningioma is a benign tumor entity featured with massive inflammatory cell infiltration and often less proportion of meningothelial elements. Surgical resection remains the treatment of choice. This is the first report regarding cystic LPRM from Indonesia; we also summarized relevant literature upto-date, May 2020, reported LPRM cases.

Background:Malignant peripheral nerve sheath tumors (MPNSTs) constitute a group of soft tissue neoplasm with neuroectodermal origin. Most cases are small at presentation and only some have been described reaching giant dimensions.Case Description:We report two cases that were diagnosed and treated as giant MPNST of the scalp. Both patients had extensive lesion on the head with intracranial infiltration. Microsurgical resection was indicated and a vascularized free flap was used to cover the defect. During follow-up the tumors recurred and further surgical excision treatment by adjuvant radiation therapy was performed.Conclusion:MPNSTs of the scalp are rare neoplasm of the peripheral nervous system. They are aggressive lesion that can recur and their management requires a multimodality approach.

Background: Almost 95% of laryngeal cancers are squamous cell carcinoma. Most of them come from the supraglottic and glottic regions. Globally from 1990 to 2017, there was an increase in the incidence of laryngeal cancer by 58.67%. Patients with suggestive grievances of laryngeal cancer symptoms are usually advised to do a further examination. The use of multimodality diagnosis is helpful for the diagnosis of cancer. Diagnostic procedures in diagnosing laryngeal cancer can be made by history and physical examination, clinical (laryngoscopy), and supporting examination (radiology and biopsy). This study aims to determine the distribution of the demographic (gender, age, domicile, marital status, and educational level), clinical distribution (voice changes, respiratory disorders, pain, dizziness, cough, lump on the neck, and others), and modalities of diagnosis (anamnesis, clinical examination, radiology, and biopsy) in laryngeal cancer.Methods: Descriptive study and a routine data-based study was conducted by collecting data on cancer patients who were diagnosed with laryngeal cancer from 2003 to 2007 by the microscopic either in Dharmais National Cancer Hospital (DNCH) or other hospitals. The study sample was 53 out of a total of 68 cases of laryngeal cancer who had been diagnosed with malignancy histopathologically at DNCH or in other hospitals with epithelial or non-epithelial types with completed medical records. Results: The glottic region is the most common subsite, that is, 52.8%, and squamous cell carcinoma (SCC) is the most common histopathological type of laryngeal cancer. In most of the cases, either males or females presented with a change in the voice of 68.8% and 80% respectively. In 6 out of 12 cases have not been examined microscopically before, while 7.5%.of the cases have done the diagnostic procedure completely in DNCH. Conclusions: The most common subsite and histopathological type of laryngeal cancer is glottis and SCC. The most common clinical feature in both sexes is voice changes. Most cases have not been examined according to the standard diagnosis procedure completely.

Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan, sikap, dan tindakan pola hidup masyarakat kelurahan utan panjang terhadap covid-19 - jakarta pusat. Metode penelitian menggunakan Deskriptif kuantitatif dengan variabel independen mengetahui tingkat pengetahuan, sikap, dan tindakan pola hidup masyarakat dan variabel dependen covid-19 - Jakarta Pusat. Sampel yang diambil dengan teknik Random Sampling. Besarnya sampel dalam penelitian ini dapat diketahui dengan cara menggunakan rumus Slovin, Jumlah sampel adalah 340 responden. Menggunakan Kuesioner dalam pengumpulan data, data yang di dapat dianalisis menggunakan IBM SPSS 24. Hasil uji univariat didapatkan persentase terbesar pada usia 18 – 30 tahun (30,9%, 105 responden), jenis kelamin perempuan (51.5 %, 175 responden), dan pendidikan SMA/SMK (55,6%, 189 responden). Dengan jumlah responden yang masuk dalam tingkat pengetahuan kategori kurang (84 responden), cukup (157 responden), dan baik (99 responden) dari total responden sebanyak 340 responden. Dengan jumlah responden yang masuk dalam sikap kategori kurang (90 responden), cukup (12 responden), dan baik (238 responden) dari total responden sebanyak 340 responden. Sedangkan jumlah responden yang masuk dalam pola hidup kategori kurang (31 responden), cukup (63 responden), dan baik (246 responden) dari total responden sebanyak 340 responden. Hasil uji bivariat menggunakan metode Pearson correlation didapatkan bahwa adanya hubungan antara mengetahui tingkat pengetahuan, sikap, dan tindakan pola hidup masyarakat kelurahan utan panjang terhadap covid-19 - Jakarta Pusat.

Background: Lung cancer is the most common cancer incidence in population and in hospitals. According to GLOBOCAN 2012 , the incidence of lung cancer in male is 25.8/100,000 with a death rate of 23.2/100,000 while in female 8.1/100,000 with a mortality rate of 7.3/100,000. From the national data, out of 14 provinces (2008-2012) in Indonesia, incidence of lung cancer in male was ranked first, 2.31/100.000. Meanwhile in female was the fifth, 1.08/100.000. Immunotherapy is a novel treatment for many types of malignancy including lung cancer. Currently one of monoclonal antibody against programmed cell death 1 (PD-L1) has been approved for non–small cell lung cancer (NSCLC) with a companion diagnostic by Dako. Ventana's benchmark XT is widely used immunohistochemistry platform. However, data on its reliability and reproducibility with 22C3 antibody in Indonesia are scant. Aim: Immunohistochemistry Dako's anti PD-L1 can be applied in Ventana platform. This protocol could be used in preliminary study for lung cancer in 14 designated national referral cancer hospital in Indonesia. Methods: Lung cancer is the most common cancer incidence in population and in hospitals. According to GLOBOCAN 2012 , the incidence of lung cancer in male is 25.8/100,000 with a death rate of 23.2/100,000 while in female 8.1/100,000 with a mortality rate of 7.3/100,000. From the national data, out of 14 provinces (2008-2012) in Indonesia, incidence of lung cancer in male was ranked first, 2.31/100.000. Meanwhile in female was the fifth, 1.08/100.000. Immunotherapy is a novel treatment for many types of malignancy including lung cancer. Currently one of monoclonal antibody against programmed cell death 1 (PD-L1) has been approved for non–small cell lung cancer (NSCLC) with a companion diagnostic by Dako. Ventana's benchmark XT is widely used immunohistochemistry platform. However, data on its reliability and reproducibility with 22C3 antibody in Indonesia are scant. Results: The Ventana's Ultraview 22C3 optimized protocol stratified the PD-L1 expression. Three out of 10 cases were strongly positive. Some of these had squamous differentiation. Weakly positive was only found in 1 case of adenocarcinoma. The last 6 cases showed negative expression on PD-L1 which 2 of these cases were the specimens from cryosurgery. Conclusion: The results of laboratory immunohistochemistry assay demonstrate than Dako's anti PD-L1 primary antibody can be applied to Ventana's benchmark XT platform. Start conducting study of lung cancer in Indonesia's in 14 designated national referral cancer hospital in provinces profile of PD-L1 expression in Dharmais NCC. The detection of PD-L1 protein expression in NSCLC using Ventana platform can be used to determine which NSCLC patient is eligible for anti-PD1 based immunotherapy.