Bortezomib is the first therapeutic proteasome inhibitor used for cancer treatment. The redox behaviour of bortezomib was investigated over a wide pH range. Bortezomib undergoes electrochemical oxidation and reduction in independent mechanisms. The oxidation of bortezomib is pH‐dependent for pH<7.5 and occurs with the transfer of one electron and one proton involving the formation of two electroactive oxidation products. The reduction of bortezomib is quasi‐reversible, pH‐dependent, involving the transfer of two electrons and two protons and does not involve the formation of electroactive products. The value of pKa≈7.5 was determined. Mechanisms for oxidation and reduction were proposed.

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Semintele de Carthamus tinctorius L., sunt recunoscute pentru potentialul lor energetic. Capacitatea lor germinativa alaturi de alte caracteristici ce tin de variabilitatea genetica au fost putin studiate. Astfel, in acest sens in cadrul acestei lucrari ne-am propus sa studiem mobilizarea rezervelor din semintele soiului de sofranel Brigea, pe parcursul procesului de germinatie, in vederea stabilirii punctelor de cumul maxim ai caracteristicilor analizate.The used biological material consists of safflower seeds in different germination stages (seeds -S I, seedlings -S II, plantlets -S III, plants without roots -SIV, roots -S V). The extracts were obtained using phosphate buffer pH 7. Plant extracts were subjected to the following analysis: spectrophotometrically determination of total protein content, phenolic and flavonoid content.With regard to the total protein content of the analyzed extracts, the highest values were and 9.1 g/100g FW, recorded in S III stage. Also, the total flavonoid content during the germination stages ranged between 0.08g and 0.21g rutin equivalent (RE) / 100g FW. The highest value of phenols during seed germination was performed in the S III with 1.08 g gallic acid equivalent (GAE).The obtained results show that the bioaccumulation of phenolics and protein content in safflower during seed germination is influenced by the germination stage, impunand investigatii viitoare asupra procesului de germinatie si a posibilitatii de valorificare in domenii conexe.