This study shows that the abnormal neutral lipid composition of all three TG-rich lipoprotein particles and increased concentrations of Lp-A-II:B:C:D:E particles represent the main factors affecting the in vitro lipolytic rates of VLDL + IDL substrate in both the CRF patients before dialysis and patients on hemodialysis.

VLDL, very low density lipoproteins (d < 1.006 g/cm3; St = >20); LDL, low density lipoproteins (d 1.006-1.063 g/cm3; Si = 0-20);HDL3, high density lipoproteins (d 1.125-1.21 g/cm3); ai-LP, a-lipoproteins, lipoproteins with an electrophoretic mobility of ai-globulins; 0-LP, 0-lipoproteins, lipoproteins with an electrophoretic mobility of 0globulins. Abbreviations based on the chemical classification of lipoproteins are: LP-A, lipoproteins characterized by the presence of apolipoprotein A; LP-B, lipoproteins characterized by the presence of apolipoprotein B; LP-C, lipoproteins characterized by the presence of apolipoprotein C; LP-X, lipoproteins occurring in obstructive jaundice and characterized by the presence of a protein moiety consisting of 40% albumin and 60% apolipoprotein C; ApoA, apolipoprotein A, protein moiety of LP-A; ApoB, apolipoprotein B, protein moiety of LP-B; ApoC, apolipoprotein C, protein moiety of LP-C and LP-X. At the present time the apolipoproteins could be characterized by terminal amino acids and antigenic determinants as follows: ApoA, aspartic acid as N-terminal and threonine and glutamine as C-terminal amino acids, and at least two antigenic determinants; ApoB, glutamic acid as Nterminal and serine as C-terminal amino acid, and a single antigenic determinant as LDL; ApoC, threonine and serine as N-terminal and valine and alanine as C-terminal amino acids, and at least three antigenic determinants.

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