There was an association between the use of drugs with anticholinergic properties and the probability of hip fracture in elderly patients and it was possible to establish the level of risk.

People who are taking opioids and benzodiazepines have increased risk for hip fracture in Colombia. Strategies to educate physicians regarding the pharmacology of older adults should be strengthened.

ResumenLos inhibidores de la bomba de protones (IBP) son los supresores de la secreción gástrica más efectivos y se encuentran entre los medicamentos de mayor formulación y venta en Estados Unidos; en algunos casos son prescritos sin indicación justificada. En años recientes, el reporte de reacciones adversas importantes relacionadas con su uso ha suscitado preocupación. Sin embargo, la calidad de la evidencia no ha sido concluyente y, en algunos casos, la magnitud del riesgo no es de importancia clínica. El objetivo de esta revisión es presentar la evidencia disponible frente a los eventos adversos de mayor importancia relacionados con los IBP. Palabras claveInhibidores de la bomba de protones, efectos colaterales y reacciones adversas relacionadas con medicamentos, medicina basada en evidencia, farmacovigilancia (fuente: DeCS). AbstractProton pump inhibitors (PPIs) are the most effective gastric secretion suppressors and are among the most widely prescribed and widely available drugs in the United States of America. In some cases they are prescribed without justification. In recent years, concerns have arisen over reports of major adverse reactions related to the use of PPIs. However, the quality of the evidence has not been conclusive, and in some cases the magnitude of the risk has not been clinically significant. The objective of this review is to present the available evidence regarding the most important adverse events related to PPIs. KeywordsProton pump inhibitors, adverse drug side effects, adverse drug reactions, evidence-based medicine, pharmacovigilance (Source: DeCS). Revisión de tema INTRODUCCIÓNLos inhibidores de la bomba de protones (IBP) son medicamentos supresores de la secreción gástrica que actúan mediante la inhibición de H + K + -ATPasa en las células parietales del cuerpo y el fondo gástrico. Son profármacos que al ser ingeridos pasan a la circulación general y se difunden por las membranas de las células parietales hasta los canalículos, en donde el pH ácido (alrededor de 0,8) induce la formación de una sulfonamida tetracíclica que se une covalentemente con los grupos sulfidrilo de los aminoáci-dos cisteína en la H + K + -ATPasa inactivándola irreversiblemente e inhibiendo la secreción ácida gástrica hasta que nuevas bombas de protones son sintetizadas. Actualmente hay disponibles cinco IBP en el mercado: omeprazol, esomeprazol, lansoprazol, pantoprazol y rabeprazol, los cuales

Malaria in children is still an important public health problem in endemic areas of South-East Asia and Latin America. Certain forms of the disease, such as Plasmodium vivax severe malaria, are still neglected. This descriptive study assessed the frequency of severe and benign P. vivax infection in Emberá children (<14 years of age) from an endemic municipality in Colombia in 2013, using the WHO criteria. During 2013, 270 Emberá children presented 349 episodes of malaria. From them, 22 (8.1%) presented at least one of the criteria for severe malaria. Some patients with P. vivax presented with severe malaria (severe anemia, renal dysfunction, respiratory distress and seizure). Mixed malaria cases presented more complications than those with monoinfection (OR=5.535; 95%CI 1.81-16.9). In Colombia, few data are available about severe P. vivax malaria in children, especially in the Amerindian ethnic groups. Mixed infections were associated with increased risk of severe malaria. At the same time, detailed and prospective studies are needed to measure the real impact of severe vivax malaria, as was evidenced in this paper.

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