Objective: To evaluate the effects of a 10-week resistance training program in patients. Methodology: A group of eleven subjects (7 women and 4 men) with multiple sclerosis with a range in the “Expanded disability status scale” score between 6 and 8, mean age 46.45 ± 6.89 years-old, participated in this investigation. It was carried out a 10-week resistance program, twice per week, complemented with a physiotherapy session. Sample was divided in walking group and in the non-walking group. Measurements of strength, balance, body composition and quality of life were taken before and after the intervention program. Results: Significant differences were found in the variables load (kg), total medium strength (N), maximum strength (N), total medium power (W) in the bench press and squat in the walking group and in shoulder extension test in the non-walking group; and interpersonal relationships, physical and psychological health, by the application of “WHOQOL -BREF” questionnaire. There were no significant differences in balance and body composition variables. Conclusion: The 10-week strength training program in patients with multiple sclerosis with a score between 6 and 8 on the scale “Expanded disability status scale” showed improvements at a psychological, social and physical levels. About strength variables, it was found improvements that could improve functionality in the activities of daily life. Furthermore, balance test and body composition did not show significant changes in both groups.