The Rubiaceae tribe is one of the largest tribes in the plant kingdom which has around 13.150 species of plants, shrubs, and trees with 611 genera, the largest in the tropics on earth. The components of chemical compounds in this tribal plant that function as antibacterials are flavonoids, saponins, tannins, and alkaloids. In compiling this review article, the technique used is to use literature studies by finding sources in the form of primary data or the form of official books, national journals, and international journals. Search data using online media with the keywords Antimicrobial, Rubiaceae. Search for the main references used in this article through trusted websites such as Pubmed, Google Scholar. Based on the results of the literature data that has been done, it can be concluded that the zone of inhibition of both have an inhibition zone of > 30 mm which is categorized as a very strong antibacterial activity.