The study was carried out to investigate the protective effects of bi-herbal formulation of aqueous extracts of Vernonia amygdalina and Gongronema latifolium against gentamicin induced nephrotoxicity and liver injury in rats. Forty (n=40) male Wistar albino rats were procured and separated into five groups. Groups I and II served as normal control and experimental control respectively. Groups III to V served as test groups. Rats of experimental control (group II) and test groups were induced with lethal dose of gentamicin. Test groups III and IV were placed on herbal formulation of aqueous extracts of V .amygdalina and G. latifolium respectively, whereas rats in test group V received bi-herbal formulation of aqueous extracts of V. amygdalina and G. latifolium. Nephrotoxic indices such as urea reduced significantly (p<0.05) in test groups (III, IV, and V) when compared to experimental control (group II) and normal control (group I). Creatinine also reduced significantly (p<0.05) in test groups III and V against group II (experimental control), and increased insignificantly (p>0.05) in test group V when compared to normal control (group I). Rats induced with gentamicin had upsurge in liver enzymes indicating possible compromise of hepatocellular integrity but the ameliorating effects of the herbal formulations were seen clearly in test groups in this study as they tried to protect the hepatocellular integrity. The bi-herbal formulation of aqueous extract of 5% v/v each of V. amygdalina and G. latifolium offered the best protection as observed in this study. This study has revealed the protective effects of bi-herbal formulation of aqueous extract of V. amygdalina and G. latifolium against gentamicin induced nephrotoxicity and liver injury in rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.