A field experiment on "Impact of different herbicides on weed control in grape (Vitis vinifera L.) cv. 2A Clone" was carried out during October 2019 to March 2020 at fruit orchard, Main Horticultural Research and Extension Center (MHREC) Sector no 70, University of Horticultural Sciences, Udyanagiri, Bagalkote, to test the effect of various herbicides for controlling weeds in the vineyards under dry zone climate of north Karnataka. The trial was laid out in randomized complete block design (RCBD), having ten treatments with three replications. Lower number of total weeds/m 2 4.67, 9.00, 16.00 and 23.00/m 2 at 30, 60, 90 and 120 days after spraying was recorded with T6-tank mix post-emergent application of oxyfluorfen 23.5% @ 1.0 lit/ha + glyphosate 41% SL @ 2.62 lit/ha. Among different herbicides, the higher yield per hectare (32.31 t/ha) and the lower weed index (5.76 %) were recorded with tank mix post-emergent application of oxyfluorfen 23.5% @ 1.0 lit/ha + glyphosate 41% SL @ 2.62 lit/ha. No phyto-toxicity symptoms viz. leaf tip/surface injury, wilting, vein clearing, necrosis, epinasty and/ or hyponasty were observed.