Clinical usage of two different flow anesthesia forms with desflurane may increase interleukin-10 levels both in Group HF and Group LF; nitric oxide levels circulating concentrations were significantly reduced at times t1 and t2 compared with preoperative concentrations; however, at 24h postoperatively they were higher in Group LF compared to Group HF. No correlation was detected between interleukin-10 and nitric oxide levels.

This prospective, randomised study examined the effect of injection speeds for unilateral epidural anesthesia on block characteristics, hemodynamic parameters, and discharge criteria in 60 patients. Levobupivacaine 5% was administered to Group F over 1 min (fast) and to Group S over 3 min (slow) (n=30 each) with the needle angulated at 5°-10° from the midline. Unilateral epidural block was significantly more successful in Group S than in Group F (70.3% vs. 16%; p<0.001). On the non-operated sides in group S, the maximal sensorial block time was shorter and the regression time for 2 segments was longer (p<0.05). And the walk-out time was longer in group F (p<0.05). We consider that the slow administration of local anesthetic in unilateral epidural anesthesia is more effective than rapid administration.

AIM: The aim of this study was to investigate blood glucose level of desfl urane and sevofl urane on blood glucose in diabetic rats undergoing acute hyperglycemia. MATERIALS AND METHODS: In this study, 30 male Wistar albino rats were included. Diabetes was induced by a single IP injection of streptozotocin. After the effects of chronic diabetes encountered, diabetic rats were randomly assigned into diabetic control (group DC), diabetic hyperglycemia group (group DH), diabetic hyperglycemia group with desfl urane (group DH-D), and diabetic hyperglycemia group with sevofl urane (group DH-S) groups. The normoglycemic groups received an IP injection of the same amount of saline. Hyperglycemic diabetic rats were anaesthetized by desfl urane 6 % or sevofl urane 2 % at a dose, by which minimal alveolar concentration (MAC) for rats would be one. The drugs were given for 4 hours within 100 % oxygen at a rate of 6 L.min -1 . One hour after cessation of inhalation anesthesia, blood glucose levels were determined at 1st, 4th and 24th hours. 24 hours after the anaesthesia. RESULTS: Serum glucose was detected to be signifi cantly lower in Group C, when compared to Groups DC, DH, DH-D and DH-S (p = 0.002, p = 0.001, p = 0.002, p = 0.003, respectively). Blood glucose levels in the diabetic groups were similar at the end of 6 weeks period, after hyperglycemia and anaesthesia induction. CONCLUSION: We found out that sevofl urane and desfl urane administrations in hyperglycemic rats were both related with insignifi cant blood glucose level increase at early post anaesthesia period and at post anaesthesia 24th hours. We still think that patients undergoing anaesthesia protocols with acute hyperglycemia need relatively longer follow up periods (Tab. 1, Ref. 28). Text in PDF www.elis.sk.

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Clinical usage of two different flow anesthesia forms with desflurane may increase interleukin-10 levels both in Group HF and Group LF; nitric oxide levels circulating concentrations were significantly reduced at times t1 and t2 compared with preoperative concentrations; however, at 24h postoperatively they were higher in Group LF compared to Group HF. No correlation was detected between interleukin-10 and nitric oxide levels.