Purpose: To design a transdermal norethisterone (NE) Weight variation, thickness, tensile strength, and the interaction between drug and film excipient were evaluated. The films were also characterized by Fourier transform infrared spectroscopy (FT-IR). In vitro drug dissolution and release from the transdermal patches (coded C-L, C-T, H-L and H-T) were evaluated. Results: There was significant difference between the batches in terms of in vitro drug release (p > 0.05). Dissolved drug was significantly higher in H-T film when compared to C-L film (p < 0.05). İn addition, drug release was significantly higher from H-T patch than from C-L patch (p < 0.05). Conclusion