The article provides information on the effect of pesticides - butylcaptax and droppa on respiration and oxidative phosphorylation of liver mitochondria in rat rats and their embryos. It has been shown that butylcaptax and droppa reduce the oxidation of succinate and α-ketoglutarate in the V4*, V3 and Vdnf states and drug conjugation in the liver mitochondria of pregnant animals and their embryos. The most significant inhibition of ADF formation in the respiratory chain of fatal and maternal liver mitochondria occurs via the NAD-dependent pathway, especially when poisoning with butylcaptax on the 19th day of pregnancy. Apparently, inhibition of ADF-stimulated respiration is associated with inhibition of electron transfer along the respiratory chain or is a consequence of inhibition of the transport of phosphate or ADF into mitochondria, which plays a key role in the mechanism of oxidative phosphorylation. A decrease in the conjugation of oxidation and phosphorylation does not create conditions for the accumulation of energy in an utilizable form - in the form of ADF.

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Aims: This work is aimed to investigate microflora formation, quantitative and qualitative features of various bacteria colonization in the women in labor, and newborns depending on the microbiological profile and locality altitude. Rationale: Physiological and social adaptation of newborns in extreme climate of mountains, in particular the microflora formation in unusual conditions studied. Findings: In the study of nasal microflora, the C. albicans species in case of women in labor were 77.7%, while in the newborns C. albicans species were 2 times less. In lowlands, the S. aureus type was prevailed, while in case of midlands prevailed bacterium was S. epidermidis. In the newborns of highlands, E. coli was prevailed, as in the examined lowlands, it found as 75%. In the women in labor, C. albicans were detected as 56.6%, C. krusei was 36.6%, S. aureus was 23.3%, S. epidermidis was 60% and E. coli was 30%. In newborns, representatives of candida fungi found: C. albicans was 3.3%, C. krusei was 26.6%, S. aureus was 43.3%, S. epidermidis was 53.6% and E. coli was 36.6%. Conclusions: In this work, we determined bacterial microflora colonization in throat, nasal, vaginal, urinoculture and skin swab of women in labor and newborns in lowland, midland and highland conditions, respectively.