Summary:Local vascular and traumatic involvement are well-recognized causes of anterior tibial compartment syndrome (ATCS) terminating as myoneural ischaemia. However, in a large number of patients the cause of ATCS remains unidentified. We document the occurrence of bilateral ATCS in a patient of hypothyroidism, to our knowlege a previously unrecorded association.

ABS TRACTColorectal cancer (CRC) is a worldwide problem, with an annual incidence of approximately 1 million cases and an annual mortality of more than 500,000. CRC is the second most common cause of cancer mortality among men and women. M ost CRCs arise from sporadic adenomas, and a few from genetic polyposis syndromes or inflammatory bowel diseases. Screening of CRC can be done by Computerized Tomography (CT) Colonoscopy, Sigmoidoscopy, virtual colonoscopy, Fecal Immuno-histochemical Test (FIT), Fecal Occult Blood Testing (FOBT) are used for diagnosis and Capecitabine Adrucil Avastine Bevacizumab, Camptosar, Cetuximabet are the drugs used in the colon cancer. Adrucil (Fluorouracil), Efudex, Erbitux (Cetuximab), Fluoroplex (Fluorouracil), Irinotecan Hydrochloride etc. drugs are used in rectal cancer. T, N, and M categories have been determined, usually after surgery, this information is combined in a process called stage grouping expressedin roman I to IV. M ost colorectal cancers should be preventable, through increased surveillance, improved lifestyle, and, probably, the use of dietary chemopreventative agents. Some therapies also used to treat CRC like radiation therapy, angiogenesis inhibitors therapy.

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Bhawana is an important Samskara mentioned in classics by which even a small dose of a drug may be made to produce a very high result i.e. to increase its potency. Bhawana is a process of wet trituration. The Shodhita metals and minerals with specified liquid media for specified time duration and convert them into finer assimiliable form. Liquid media help in conversion of course powder to finer state. Impregnation of properties of media to the material which lead to unique and suitable physiochemical changes helping in incorporation of organic properties to inorganic substances. It is a systematic procedure of enhancing therapeutic qualities in individual drug as well as formulations. Bhawana exert constant pressure and frictional force. The toxic effects and unwanted properties may be neutralized because of influence of Bhawana dravya. Therefore, knowing of Bhawana Dravya mentioned during various Bhasma and formulation preparation has an important role. By virtue of which it loses and decrease the soluble impurities/ toxic property of the material and results in impartation of desirable therapeutic effects.

In Ayurveda natural substances like herbs, minerals, fats, metals, animal and marine products are used for the management of various ailments. These natural products can be used directly or after specified procedure. Due to change in habitats and effect of environmental factors there may be change in chemical constitution of these products. For drug efficacy and its reproducibility of therapeutic results, it is essential to standardize the products. Skin diseases account for 10 -20 % of all consultations in general practice. Most common skin complaints are Dermatitis, Eczema, Acne, Urticaria, Psoriasis, skin allergy etc. There are many therapeutic forms of drugs described in classical texts, like vati / gutika (tablets), churna (powder), asava and arista (self-generated alcohol based elixir), snehakalpana (processed medicated oil / skimmed milk fat (ghrita), etc. for skin disorders. Medicated ghritakalpana (GK) are mainly used to alleviated and manage vitiated Vatadosha and Pittadosha. Panch Tikta Ghrita (PTG) is most commonly used GK preparation as Ayurvedic medicine for treatment of skin disorders, as herbs (panchtikta) are best among raktashodhaka (blood purifier) and ghrita is good for skin as well as to pacify vitiated pitta and Vatadosha. Three batches of PTG was prepared with Vasa (Adhatoda vasica), Nimba (Azadirachta indica), Guduchi (Tinospora cordifolia), Kantakari (Solanum surattense), Patola (Tricosanthes dioica) and ghrita (cow's milk fat) in accordance with Sharangdhar Samhita Madhyamkhanda 9/89-90. Analytical study for standardization was carried out on basis of classically illustrated organoleptic tests and modern parameters of physico-chemical properties like Loss on drying at 110°C, Refractive Index at 40°C, Acid value, Saponification value, Iodine value, Ester value, Peroxide value, Weight per ml, Specific gravity (melted), Melting Point (in °C) and Qualitative Tests was carried out through estimation of Carbohydrate, Protein, Alkaloid, Cardiac glycoside, Flavonoid, Anthraquinone glycoside, Tannin, Steroid, Triterpenoid and Thin Layer Chromatography was done. All test showed a significance changes after processing from raw ghrita. It shows that ghrita incorporates many properties of panchtikta herbs and in this way a range of parameter is established for re-production and therapeutically effectiveness of PTG in standard manner.