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This chapter presents the design of JAYA-FOPIDC to inject the optimal dose of insulin through the MID for blood glucose (BG) regulation in Type-I diabetes mellitus (TIDM) patients. In this strategy, the controller parameters are tuned based on the JAYA optimization technique for better control execution. The capability of the JAYA-FOPIDC as to accuracy, robustness and stability is tested by use of MATLAB and SIMULINK. The procured outputs reveal the better implementation of JAYA-FOPIDC to regulate the BG level within the range of normoglycemia (70-120 mg/dl). The justification of improved control execution of the JAYA-FOPIDC is revealed by the relative result examination with different prominent control techniques.

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