Abstract:Iron deficiency is the most common nutritional deficiency state of women in childbearing age. Peri-partum iron deficiency anaemia (IDA) is associated with significant maternal, fetal and infant morbidity. An effective management is needed to prevent adverse outcomes. Current options for treatment are limited; these include oral iron supplements, which are usually ineffective and poorly tolerated, and whole blood transfusion, which carries an inherent risk, should be avoided during pregnancy. Intravenous ferric carboxymaltose is a new treatment option and it is better tolerated with a good result. The study was designed to assess the safety and efficacy of intravenous ferric carboxymaltose for correction of IDA in pregnant women in third trimester. It was a prospective study; 260 anaemic pregnant women received Injection ferric carboxymaltose, as a total dose of 500-1000 mg between 28 to 36 weeks of pregnancy. Safety was assessed by analyzing adverse drug reactions. Ferric carboxy maltose significantly increased Hb level (p<0.001) in all women in this study group. Increased Hb value was observed 3-4 weeks after infusion. None of the women felt worse. No serious adverse effects were found and minor side effects occurred in 34(13%) patients.Our study revealed that the Hb level increased significantly, was well tolerated and without significant side effects.

Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder responsible for subfertility in young women. The aim of the study was to compare the efficacy of Letrozole over Clomiphene citrate (CC) for ovulation induction in patients with PCOS. It was a prospective randomized trial in a private practice setting. The study period was 3 years, which includes 240 sub fertile patients with PCOS. Patients were divided into two groups. Group-A: 120 patients got Letrozole (2.5 mg) tab, 2 tabs once daily from D 2 -D 6 for 3 cycles. Group-B: 120 patients took tab. Clomiphene citrate (50mg), 2 tabs once daily from D 2 -D 6 for 3 cycles. Trans-vaginal ultrasound was done on D 12 -D 13 to document number of follicles, measurement of dominant follicle and endometrial thickness. Ovulation and pregnancy rate was measured. Results showed that Letrozole have significantly better effect on endometrial thickness (Let 9.2 mm vs CC 8.1 mm) and pregnancy rate (Let 44% vs CC 24%). In CC, multiple follicles were found (CC 44% vs Let 30%). Ovulation occurred in 65% with Letrozole group and 64% in CC group without a significant statistical difference. The study concluded that Letrozole have better effect for induction of ovulation in PCOS patient in comparison to CC.

Preeclampsia is a pregnancy specific, multi-system disorder of unknown etiology characterized by new onset of elevated blood pressure & proteinuria after 20 weeks of gestation. Globally preeclampsia and other hypertensive disorders of pregnancy are a leading cause of maternal and infant illness and death. But the exact pathophysiology is yet to be explored. It was a case control study and was conducted during the period of January 2010 - December 2010 in the department of Obs & Gynae DMCH and dept. of Biochemistry of BSMMU. The main objective of the study was to evaluate the association of serum ferritin and iron in preeclampsia & eclampsia. A total 100 pregnant women were included in this study. Of them 50 preeclamptic or eclamptic, nonanaemic patients not in labour (26-40weeks) were taken as case and 50 normotensive pregnant women were taken as control. Mean Serum ferritin level in case and control group was 100.03 ± 123.52 ?gm/L and 31.53 ± 20.86 ?gm/L respectively which is highly significant (P< 0.001). Out of 50 cases ferritin level was raised in 10 cases (20%). In 80% cases ferritin level was below the cut-off value that is normal or below normal but in 100% of controls had ferritin level below the cut off value. DOI: http://dx.doi.org/10.3329/fmcj.v8i1.16892 Faridpur Med. Coll. J. 2013;8(1): 18-21

Female genital fistula is a serious medical condition in which a perforation develops most commonly between bladder and vagina (VVF). Although the majority of genitourinary fistulas can be closed surgically, the successful closure depends on many factors. In this retrospective study, the records of 30 women with a mean age of 23.8 years were assessed; 13% of the VVF occurred after abdominal hysterectomy, 67% after Caesarean section, and 20% after difficult vaginal delivery. Six (20%) women had previous repair. The median duration of the VVF was 5.9 months. Of the 30 patients of VVF, 24 were high and 6 were low. Twenty seven had single fistula opening and 3 had two fistulous openings. An abdominal approach was used in 24 patients and vaginal approach in 6 patients. At a mean follow up of 24 months, the VVF was cured in 90% patients. In conclusion, surgical correction of the VVF is more successful when done earlier, probably in the first 6 months. Abdominal approach seems to be more successful technique and recurrent VVF being associated with lower success rates than primary repair. High variety also has good result.

not available Faridpur Med. Coll. J. Jul 2018;13(2): 56-57