AIM: This study was carried out to investigate cytotoxic activity towards T47D, 4T1, MCF-7, HeLa, and Raji cells of alkaloid fractions of Zanthoxylum acanthopodium DC. fruits. Zanthoxylum acanthopodium DC. METHODS: The fruit was extracted by maceration. The ethanol extract was fractionated with liquid-liquid extraction using n-hexane, chloroform at pH 3,7, and 9 to obtained alkaloid fractions. Cytotoxic activity for fraction chloroform at pH 7 and 9 was determined with MTT assay. RESULTS: The IC50 of fraction chloroform at pH 7 and 9 was (92.67 ± 1.37; 71.87 ± 1.04; 159.87 ± 0.63; 123.39 ± 0.81; and 103.09 ± 0.58 µg/mLfor pH 7) and (451.29 ± 25.48; 247.18 ± 2.82; 318.46 ± 5.40; 303.96 ± 8.75; and 181.45 ± 1.35 µg/mL for pH 9) respectively. CONCLUSION: The results reveal that alkaloid fractions at pH 7 and 9 of Zanthoxylum acanthopodium DC. Fruits have cytotoxic activity. Our further study is to isolate and assesses anticancer activity from alkaloid compounds.

Teh-tehan (Acalypha siamensis) is a plant that has many branches including a bush with a height of 1-2 m. Escherichia coli bacteria can be found in the human intestine, most of these bacteria are harmless, but some can cause serious poisoning in humans such as diarrhea. The purpose of this study was to determine the antibacterial activity of the ethanol extract of tea-tea leaves (Acalypha siamensis) against Escherichia coli bacteria using the disc method. This research is descriptive by using the ratio of the extract concentration of 20%, 30%, 50%, and 80% with a positive control of chloramphenicol and a negative control of aquadest. he results showed that the concentration of ethanol extract had antibacterial activity. Escherichia coli bacteria gave the highest inhibition zone at a concentration of 80% with an inhibition zone diameter of 12.8 mm while the control chloramphenicol was 28.5 mm. Based on the ANOVA data analysis test that there is a significant difference in antibacterial inhibition.

Penyakit infeksi merupakan masalah utama yang terjadi di negara berkembang disebabkan adanya mikroorganisme patogen pada tubuh manusia.Terapi antibiotik yang diberikan pada pasien rawat inap Rumah Sakit Umum Imelda Pekerja Indonesia Medan seperti golongan β-laktam, sefalosporin, makrolida, quinolon dan tiamphenicol. Penggunaan terapi antibiotik oral terbanyak pada tahun 2018 adalah amoxicillin dan levofloxacin. Penelitian ini bersifat observasional yang dilakukan secara retrospektif dan dianalisa dengan metode statistik deskriptif. Analisa dengan metode statistik hanya berhubungan dengan bagaimana menguraikan atau memberikan keterangan mengenai suatu data, keadaan, dan fenomena sehingga mudah dipahami. Pengolahan data menggunakan program SPSS 21. Hasil penelitian diperoleh antibiotik oral yang paling banyak digunakan adalah adalah cefadroxil 83 (18,5%) dan antibiotik sedikit INH 1 (0,2%).Penggunaan antibiotik oral pada pasien rawat inap di Rumah Sakit Umum Imelda Pekerja Indonesi tahun 2019 sudah sesuai dengan formularium Rumah Sakit.

Gastritis is an inflammatory process in the gastric mucosa and gastric mucosa. Gastritis is a state of inflammation or bleeding off the gastric mucosa that is acute, chronic, diffuse, or local. Gastritis or heartburn is an inflammation of the stomach wall, this disease is often found to arise suddenly which is usually characterized by nausea or vomiting, bleeding pain, weakness, decreased appetite or headache. The purpose of this study was to determine the PPI class of drugs most widely used by outpatients with gastric gastritis disorders. Knowing the factors that most often influence of gastric gastritis disorders.To find out the age most often affected by gastric gastritis. This research method used an observational method with the research design used was data collection carried out retrospectively, namely by tracing records at the outpatient installation of Imelda Hospital Medan from January 1 to December 31, 2019. The data obtained at the installation is descriptive and evaluate the use of PPIs with the treatment of gastritis aimed at improving the patient's quality of life, relieving complaints, curing gastritis, preventing recurrences and complications.  Besed on the results of the study, the most outpatients with gastritis at the Imleda Hospital Medan were 15 women (17%), 6 men (29%), And the most commonlyused PPI drugs for gastritis patients were lansoprazole in 18 patients (86%), Omeprazole 3 patients (14%).