Considering the increasing demand to flavored milk and nutritional, therapeutic and post meal mouth freshener property of Piper betel leaves the present study was undertaken with object to optimize the levels of Piper betel leaves for developing flavoured milk and to study the sensory qualities as well as physico-chemical properties of Piper betel flavoured milk. Initially fresh cow milk was standardized to 2% fat and aqueous extract of piper betel leaves (PBLE) of different verities were prepared. The level of PBLE and sugar were optimized using CCRD of RSM. It was found that the flavoured milk prepared by the addition of the PBLE of Calcutta variety had obtained maximum scored for all the sensory qualities among other two varieties under study. In RSM trial the results showed that the colour and appearance, sweetness and overall acceptability score of milk was recorded maximum for formulation, having 5 per cent PBLE and 10 per cent sugar. The best solution exerted through the software, contained PBLE and sugar at 5.15 and 10.30 per cent, respectively. The validation of the prediction was done by actual observations recorded for sensory score. The optimized formulation had 8. 49, 8.50, 7.40, 8.30 and 8.15 score for colour and appearance, flavour, consistency, sweetness and overall acceptability, respectively. Consumers as a whole liked the product 'moderately' to 'very much' with an average score of 7.70.