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The present study was carried out to enhance solubility of Lurasidone HCl. Lurasidone HCl was selected as model drug and different carriers like Urea, Polyethylene Glycol 4000, Polyvinyl pyrrolidone K-30 were used in drug to carrier ratio 1:1, 1:3, 1:5 by weight respectively. Solid dispersions were prepared by physical mixing method and solvent evaporation method. Solid dispersions were evaluated by drug content, in-vitro release, FT-IR, DSC and XRD. The obtained data of solid dispersion prepared by solvent evaporation method were compared with physical mixing method. The result showed decrease in melting point change from crystalline to amorphous form and improved dissolution rate as compared to physical mixing as well as pure Lurasidone HCl. The finding of present study proposes that solid dispersion approach is beneficial in enhancing solubility of drug and bioavailability as well.

Abstract:We develop a theoretical model for quantitative analysis of temperature-dependent thermoelectric power of monovalent (Na) doped La 0.97 Na 0.03 MnO 3 manganites. In the ferromagnetic regime, we have evaluated the phonon thermoelectric power by incorporating the scattering of phonons with impurities, grain boundaries, charge carriers and phonons. In doing so, we use the Mott expression to compute the carrier (hole) diffusion thermoelectric power (

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