SummaryHeparin in high concentration inhibits the fibrinolysis of human plasma clots or bovine fibrin by fibrinolytic agents which produce plasminogen activation. Heparin has no effect on the fibrinolytic activity of plasmin or Aspergillus protease.In order to produce inhibition of plasminogen activation heparin requires the presence of a co-factor which is present in citrated human plasma but absent from its euglobulin fraction.In none of the concentrations tested has heparin an enhancing effect on fibrinolysis.
PTC DEFICIENCY 81 from both normal and diabetic rats responds similarly. The increased glucose-6-phosphatase activity found in liver of alloxan diabetic rats therefore does not appear to be due to any such activation mechanism, but rather due to an actual increase in the amount of enzyme present.
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